hrp0095p2-34 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Optimal 25-OH-Vitamin D level in children derived from metabolic parameters

Gillis David , Hefter Ari , Edri Edri Shalom , Strich David

Context: Optimal levels of 25-OH-Vitamin D (25OHD) for children are unknown. Prevalent population levels of 25OHD are likely to be sub-optimal since sun exposure is reduced in modern living.Objective: To deduce recommended levels of 25OHD by testing, in children, the level at which 25OHD optimally effects calcium, phosphate and parathyroid hormone levels in a population-based data.Design:</...

hrp0094p2-82 | Bone, growth plate and mineral metabolism | ESPE2021

Vitamin D - What is the Optimal Level in the Pediatric Population

Gillis David , Hefter Ari , Edri Shalom , Strich David ,

Introduction: The optimal level of 25-OH-Vitamin D in children is not clear since most studies have been performed on adults. Creating normal levels is problematic since the recommended level of vitamin D is based on the effect of vitamin D on other parameters and not upon its level in the population.Methods: This is a "big-data" study in which we analyzed Vitamin D tests from 49,935 children sampled in Clalit He...

hrp0097p2-34 | Fat, Metabolism and Obesity | ESPE2023

Case Report: Massive Obesity secondary to a Homozygous MC4R mutation in a 3-year-old Boy

Gillis David , Hefter Ari , Edri Edri Shalom , Strich David

We present a 3-year-old boy with massive obesity and hyperphagia. His appetite symptoms were evident from age 3 months, and his parents report he has an insatiable appetite, and seeks food constantly. At presentation to our clinic, his BMI was 37.21 Kg/m² [+ 6.87 SDS]. Sleep apnoea is suspected, for which he is undergoing evaluation. Parents are second cousins. Both parents are moderately obese, but his siblings are normal weight for age. The mother did not have a history...